Here's an excerpt from the abstract of Brier, S. (2009) "Cybersemiotic pragmatism and constructivism," Constructivist Foundations 5:1 (November):
"[We] must also accept as prerequisites...a pre-linguistic reality from which our bodies come.... Furthermore, we can no longer claim that there is a reality that we do not know anything about...we know that the world can produce more or less stable embodied consciousnesses that can exchange and construct conceptual meanings through embodied conversations and actions that last over time and exist in space-time and mind, and are correlated to our embodied practices. We can also see that our communication works through signs for all living systems as well as in human language, understood as a structured and progressively developed system of communication. The prerequisite for this social semiotic production of meaning is the fourfold 'semiotic star of cybersemiotics,' which includes at least four different worlds: our bodies, the combination of society, culture and language, our consciousness, and also an outer nature.
"The semiotic star in cybersemiotics claims that the internal subjective, the intersubjective linguistic, our living bodies, and nature are irreducible and equally necessary as epistemological prerequisites for knowing. The viable reality of any of them cannot be denied without self-refuting paradoxes. There is an obvious connectedness between the four worlds, which Peirce called 'synechism.' It also points to Peirce’s conclusion that logic and rationality are part of the process of semiosis, and that meaning in the form of semiosis is a fundamental aspect of reality, not just a construction in our heads."
Here's an interesting article by Humberto Maturana called "The biological foundations of virtual realities and their implications for human existence" (3:2, 2008).
"Our nervous system is continuously changing along the flow of our living, and it does so in a manner that is moment by moment contingent on the course of our living, both in our conscious and unconscious, external and internal, relational psychic space. As a result, all that we live, regardless of what kind of living we live, arises in us modulated by the history of our psychic existence regardless of whether this takes place through our living in what an observer might call a virtual or a non-virtual reality. In these circumstances, and since our structure and the structure of the medium that we bring about systemically in our living change together congruently as we live, our living becomes dependent on the virtual realities that we live as they become systemic factors in the cultural realization of our living. In other words, as we live them repeatedly, realities that were initially virtual progressively stop being virtual. As features of our culture, they become part of our biological manner of living and, hence, of the non-virtual reality that we live."